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INDO Polyclonal Antibody
CD107B; IDO; INDO
货号:YBAP11953
价格: 980/1280/1890
Immunogen: Recombinant protein of human INDO
Synonym:
CD107B; IDO; INDO
Calculated MW: 45kDa
Observed MW: Refer to figures
Source:
Rabbit
Isotype:
IgG
Reactivity: H;

Clonality: Polyclonal


Application:
WB
Purify:
Affinity purification
Concentration:
6.78mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
INDO Polyclonal Antibody


Western blot analysis of Placenta tissue, using INDO Polyclonal Antibody at dilution of 1:500

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
INDO/IDO1/indoleamine 2,3-dioxygenase (IDO) is an IFN-γ-inducible enzyme that catalyzes the rate-limiting step of tryptophan degradation. IDO is upregulated in many tumors and in dendritic cells in tumor-draining lymph nodes. Elevated tryptophan catabolism in these cells leads to tryptophan starvation of T cells, limiting T cell proliferation and activation. Therefore, IDO is considered an immunosuppresive molecule, and research studies have shown that upregulation of IDO is a mechanism of cancer immune evasion. The gastrointestinal stromal tumor drug, imatinib, was found to act, in part, by reducing IDO expression, resulting in increased CD8+ T cell activation and induction of apoptosis in regulatory T cells. In addition to its enzymatic activity, IDO was recently shown to have signaling capability through an immunoreceptor tyrosine-based inhibitory motif (ITIM) that is phosphorylated by Fyn in response to TGF-β. This leads to recruitment of SHP-1 and activatation of the noncanonical NF-κB pathway.

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