Alternative Names:

SIR2L6; SIR2-like protein 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Sirtuin 6;

Application:

WB

Reactivity:

Dilution:

WB 1:500

	Western blot analysis of extracts from CHO-K1 cells,transfected with pcDNA3.1-FLAG vector (A) or transfected with pcDNA3.1-FLAG-SIRT6 construct (B),using SIRT6 mouse mAb (1:500 diluted).

Purification:

Affinity-chromatography

Specificity:

SIRT6 Mouse mAb detects endogenous levels of total SIRT6

Immunogen:

Purified recombinant human SIRT6 protein fragments expressed in E.coli.

Description:

Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle.Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes.Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.