Alternative Names:

I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; IKKB; IkBKB; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; kinase IKK-beta;

Application:

WB

Reactivity:

Human,Rat

Dilution:

WB 1:500

	Western blot detection of IKKβ in THP-1 and PC12 cell lysates using IKKβ mouse mAb (1:500 diluted).Predicted band size:87KDa.Observed band size:87KDa.

Purification:

Affinity-chromatography

Specificity:

IKKβ Mouse mAb detects endogenous levels of total IKKβ

Immunogen:

Purified recombinant human IKKβ protein fragments expressed in E.coli.

Description:

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.