Alternative Names:

GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500

	Western blot detection of GRK2 in Ramos and THP-1 cell lysates using GRK2 mouse mAb (1:500 diluted),with super ECL.Predicted band size:80KDa.Observed band size:80KDa.Exposure time:20S.

Purification:

Affinity-chromatography

Specificity:

GRK2 Mouse mAb detects endogenous levels of total GRK2

Immunogen:

Purified recombinant human GRK2 protein fragments expressed in E.coli.

Description:

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.