Alternative Names:

caMK; CaMK IV; CaMK-GR

Application:

WB

Reactivity:

Human

Dilution:

WB 1:1000

	Western blot detection of CaMKIV in Romas and Jurkat cell lysates using CaMKIV mouse mAb (1:1000 diluted).Predicted band size:52KDa.Observed band size:55KDa.

Purification:

Affinity-chromatography

Specificity:

CaMKIV Mouse mAb detects endogenous levels of total CaMKIV

Immunogen:

Purified recombinant human CaMKIV protein fragments expressed in E.coli.

Description:

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.