Alternative Names:

CHL; chordin like 1; CHRDL1; dA141H5.1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT;

Application:

WB ICC/IF

Reactivity:

Human

Dilution:

WB 1:1000 ICC/IF 1:300

	Western blot detection of CHRDL1 in human eye and Hela cell lysates using CHRDL1 mouse mAb (1:1000 diluted).Predicted band size: 57kDa.Observed band size: 52kDa.
	Immunofluorescent analysis stain of Hela using CHRDL1 mouse mAb (1:300).

Purification:

Affinity-chromatography

Specificity:

CHRDL1 Mouse mAb detects endogenous levels of total CHRDL1

Immunogen:

Purified recombinant human CHRDL1 protein fragments expressed in E.coli.

Description:

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.