Alternative Names:

ARB1; ARR1;ARR1; ARRB1; Arrestin 2; Arrestin beta 1; Beta-arrestin-1;

Application:

WB

Reactivity:

Mouse,Rat,Human

Dilution:

WB 1:500

	Western blot detection of beta Arrestin 1 in PC12,Raw264.7,MCF7 and mouse brain cell lysates using beta Arrestin 1 mouse mAb (1:500 diluted).Predicted band size:50KDa.Observed band size:50KDa.

Purification:

Affinity-chromatography

Specificity:

β-Arrestin 1 Mouse mAb detects endogenous levels of total β-Arrestin 1

Immunogen:

Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.

Description:

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes.During homologous desensitization,beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein;the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.