Alternative Names:

FYB; ADAP; FYN-binding protein; FYN-T-binding protein; FYB-120/130; FYN binding protein; p120/p130; PRO0823; SLAP130;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500

	Western blot detection of FYB in 10,20 and 30ug Jurkat cell lysate using FYB mouse mAb (1:500 diluted).Predicted band size:120KDa.Observed band size:120KDa.

Purification:

Affinity-chromatography

Specificity:

FYB Mouse mAb detects endogenous levels of total FYB

Immunogen:

Purified recombinant human FYB protein fragments expressed in E.coli.

Description:

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells.Modulates the expression of interleukin-2 (IL-2).Involved in platelet activation.Prevents the degradation of SKAP1 and SKAP2.May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle