Alternative Names:

IMD22; LCK; Lck p56; LSK; Oncogene lck; P56 LCK; pp58 lck; Protein YT16; T cell specific protein tyrosine kinase; T lymphocyte specific protein tyrosine kinase p56lck; YT16;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:1000

	Western blot detection of LCK in Jurkat and Ramos cell lysates and using LCK mouse mAb (1:1000 diluted).Predicted band size: 58KDa.Observed band size: 58KDa.

Purification:

Affinity-chromatography

Specificity:

LCK Mouse mAb detects endogenous levels of total LCK

Immunogen:

Purified recombinant human LCK protein fragments expressed in E.coli.

Description:

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.