Alternative Names:

HD3; Histone deacetylase 3; RPD3-2; SMAP45; HDAC3;

Application:

WB

Reactivity:

Human,Mouse,Rat

Dilution:

WB 1:1000

	Western blot detection of HDAC3 in THP-1,LNCAP,MCF7,PC12,293,Jurkat,3T3 and Hela cell lysates using HDAC3 mouse mAb (1:1000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

Purification:

Affinity-chromatography

Specificity:

HDAC3 Mouse mAb detects endogenous levels of total HDAC3

Immunogen:

Purified recombinant human HDAC3 protein fragments expressed in E.coli.

Description:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.