Alternative Names:

Death receptor 5; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9;

Application:

WB ICC/IF

Reactivity:

Human,Mouse

Dilution:

WB 1:500-2000 ICC/IF 1:100

	Western blot detection of DR5 in Mouse kindey,Mouse brain,HCT116 and Hela cell lysates using DR5 mouse mAb (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.
	Immunofluorescent analysis of HeLa cells fixed by Paraformaldehyde and using DR5 mouse mAb diluted 1:100.

Purification:

Affinity-chromatography

Specificity:

DR5 Mouse mAb detects endogenous levels of total DR5

Immunogen:

Purified recombinant human DR5 protein fragments expressed in E.coli.

Description:

Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.