Alternative Names:

Prominin-1; Prominin-like protein 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:1000

	Western blot detection of Prominin-1 in CaCo2 cell lysate using Prominin-1 mouse mAb (1:1000 diluted).Predicted band size:97KDa.Observed band size:133KDa

Purification:

Affinity-chromatography

Specificity:

Prominin-1 Mouse mAb detects endogenous levels of total Prominin-1

Immunogen:

Purified recombinant human Prominin-1 protein fragments expressed in E.coli.

Description:

Binds cholesterol in cholesterol-containing plasma membrane microdomains.Proposed to play a role in apical plasma membrane organization of epithelial cells.During early retinal development acts as a key regulator of disk morphogenesis.Involved in regulation of MAPK and Akt signaling pathways.In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.