Alternative Names:

RPS6KA3; CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3;

Application:

WB

Reactivity:

Human Mouse

Dilution:

WB 1:500

	Western blot detection of RSK2 in K562,3T3 and Hela cell lysates using RSK2 mouse mAb (1:500 diluted).Predicted band size:80KDa.Observed band size:90KDa.

Purification:

Affinity-chromatography

Specificity:

RSK2 Mouse mAb detects endogenous levels of total RSK2

Immunogen:

Purified recombinant human RSK2 protein fragments expressed in E.coli

Description:

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1.

Storage Condition and Buffer:

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.