Alternative Names:

KMT5A;PR-Set7;SET07;SET8;

Application:

WB IHC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

Purification:

Affinity-chromatography

Specificity:

SETD8 Antibody detects endogenous levels of total SETD8

Immunogen:

A synthesized peptide derived from human SETD8

Description:

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specificallymonomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tagfor epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role inthe silencing of euchromatic genes.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.