Alternative Names:

BMDP; MRX; ABC15; ABCP; BCRP1

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:1000

	Western blot analysis of extract from HL-60 cells using ABCG2(CD338) Antibody

Purification:

Affinity-chromatography

Specificity:

The antibody detects endogenous level of total ABCG2(CD338) protein.

Immunogen:

Peptide sequence around aa.160~164( R-I-N-R-V) derived from Human ABCG2(CD338).

Description:

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.