Alternative Names:

ERB3, ERBB3, HER3, c-erbB3, kinase ErbB3

Application:

WB IP

Reactivity:

Human Rat

Dilution:

WB 1:500~1:2000 IP 1:30

	Western blot analysis of ErbB (HER3) expression in MCF-7 cell lysate.

Purification:

Affinity-chromatography

Specificity:

ErbB (HER3) Antibody detects endogenous levels of total ErbB (HER3)

Immunogen:

A synthesized peptide derived from human ErbB (HER3)

Description:

This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.