Alternative Names:

CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM;

Application:

WB IHC ICC/IF IP

Reactivity:

Human

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of Thrombomodulin expression in human placenta lysate.
	Immunohistochemical analysis of paraffin-embedded human bladder, using Thrombomodulin Antibody.

Purification:

Affinity-chromatography

Specificity:

Thrombomodulin Antibody detects endogenous levels of total Thrombomodulin

Immunogen:

A synthesized peptide derived from human Thrombomodulin

Description:

Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.