Alternative Names:

DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death Associated Protein Kinase 1; Death-associated protein kinase 1;

Application:

WB IHC ICC/IF

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of DAP Kinase 1 expression in HeLa cell lysate.
	Immunohistochemical analysis of paraffin-embedded human breast cancer, using DAP Kinase 1 Antibody.
	Immunofluorescent analysis of Hela cells, using DAP Kinase 1 Antibody .

Purification:

Affinity-chromatography

Specificity:

DAP Kinase 1 Antibody detects endogenous levels of total DAP Kinase 1

Immunogen:

A synthesized peptide derived from human DAP Kinase 1

Description:

DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase (DAPK) contains a “death domain” and has been shown to mediate IFN-γ-induced apoptosis. The introduction of DAPK into highly metastatic carcinoma clones lacking DAPK expression has been shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.