Alternative Names:

5T4; 5T4AG; M6P1; TPBG; 5T4 oncofetal antigen;Trophoblast glycoprotein;

Application:

WB IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IP 1:50

	Western blot analysis of 5T4 expression in MCF-7 cell lysate.

Purification:

Affinity-chromatography

Specificity:

5T4 Antibody detects endogenous levels of total 5T4

Immunogen:

A synthesized peptide derived from human 5T4

Description:

5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.