Alternative Names:

ALAS1; ALAS-H; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; ALAS3; ALASH;

Application:

WB ICC/IF

Reactivity:

Human

Dilution:

WB 1:500~1:2000 ICC/IF 1:50~1:200

	Western blot analysis of Alas1 expression in HepG2 cell lysate.

Purification:

Affinity-chromatography

Specificity:

Alas1 Antibody detects endogenous levels of total Alas1

Immunogen:

A synthesized peptide derived from human Alas1

Description:

5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.