Alternative Names:

F11R;CD321;JAM;JAM-1;JAM-A;JAM1;JAMA;JCAM;KAT;PAM-1;Junction adhesion molecule 1;

Application:

WB IHC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200

	Western blot analysis of JAM1 expression in HeLa cell lysate.
	Immunohistochemical analysis of paraffin-embedded human blader cancer, using JAM1 Antibody.

Purification:

Affinity-chromatography

Specificity:

JAM1 Antibody detects endogenous levels of JAM1

Immunogen:

A synthesized peptide derived from human JAM1

Description:

Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.