Alternative Names:

Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); ATF4; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB-2; CREB2;

Application:

WB,

Reactivity:

Human,Mouse

Dilution:

WB 1:500-1:2000

	Western blot analysis of ATF-4 (Phospho-Ser219) expression in A549 cells

Purification:

Affinity-chromatography

Specificity:

ATF-4 (Phospho-Ser219) Antibody detects endogenous levels of total ATF-4 (Phospho-Ser219)

Immunogen:

A synthesized peptide derived from human ATF-4 (Phospho-Ser219)

Description:

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.