Alternative Names:

Apoptosis regulator Bcl-2, BCL2

Application:

WB IHC IP

Reactivity:

Human

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200 IP

	Western blot analysis of BCL-2 phosphorylation expression in LPS treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

Phospho-BCL-2 (Ser70) Antibody detects endogenous levels of BCL-2 only when phosphorylated at Serine 70

Immunogen:

A synthesized peptide derived from human BCL-2 around the phosphorylation site of Serine 70

Description:

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.