Alternative Names:

Protein name C-C chemokine receptor type 5 ; Synonyms C-C CKR-5; CC-CKR-5; CCR-5; CCR5; HIV-1 fusion coreceptor; CHEMR13; CD195 antigen ; Gene name Name: CCR5 ; Synonyms: CMKBR5

Application:

WB

Reactivity:

Human,

Dilution:

WB 1:500-1:2000

	Western blot analysis on Jurkat cell lysate using Phospho-CCR5(Ser349) Antibody

Purification:

Affinity-chromatography

Specificity:

Phospho-CCR5(Ser349) Antibody detects endogenous levels of CCR5 only when phosphorylated at Sersine 349

Immunogen:

A synthesized peptide derived from human CCR5 around the phosphorylation site of Sersine 349

Description:

CCR5 a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.