Alternative Names:

NIPK; SINK; SKIP3; TRB3; Trib3; Tribbles3;

Application:

WB IP

Reactivity:

Human

Dilution:

WB 1:1000~1:5000 IP 1:20

	Western blot analysis of TRIB3 expression in 293T cell lysate.

Purification:

Affinity-chromatography

Specificity:

TRIB3 Antibody detects endogenous levels of total TRIB3

Immunogen:

A synthesized peptide derived from human TRIB3

Description:

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.