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PSMA3 Polyclonal Antibody
PSMA3; HC8; MGC12306; MGC32631; PSC3
货号:YBAP11932
价格: 980/1280/1890
Immunogen: Recombinant protein of human PSMA3
Synonym:
PSMA3; HC8; MGC12306; MGC32631; PSC3
Calculated MW: 28kDa
Observed MW: Refer to figures
Source:
Rabbit
Isotype:
IgG
Reactivity: H,M,R;

Clonality: Polyclonal


Application:
WB
Purify:
Affinity purification
Concentration:
1 mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
PSMA3 Polyclonal Antibody


Western blot analysis of JAR, A549 and PC-12 cell, using PSMA3 Polyclonal Antibody at dilution of 1:500

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of α subunits (called PSMAs), and the two inner layers are identical rings composed of β subunits. While the catalytic sites are located on the β rings, the α subunits are important for assembly and as binding sites for regulatory proteins. Seven different α and ten different β proteasome genes have been identified in mammals. PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades poly-ubiquitinated proteins). The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression.

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