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BTK Polyclonal Antibody
AGMX1; AT; ATK; BPK; IMD1; MGC126261; MGC126262; PSCTK1; XLA
货号:YBAP11948
价格: 980/1280/1890
Immunogen: Recombinant protein of human BTK
Synonym:
AGMX1; AT; ATK; BPK; IMD1; MGC126261; MGC126262; PSCTK1; XLA
Calculated MW: 76kDa
Observed MW: Refer to figures
Source:
Rabbit
Isotype:
IgG
Reactivity: H,M,R;

Clonality: Polyclonal


Application:
WB
Purify:
Affinity purification
Concentration:
2.43mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
BTK Polyclonal Antibody


Western blot analysis of Daudi cell, using BTK Polyclonal Antibody at dilution of 1:500

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
Bruton's tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinases, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of Btk is negatively regulated by PKCβ through phosphorylation of Btk at Ser180, which results in reduced membrane recruitment, transphosphorylation, and subsequent activation. The PKC inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity.

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