

工作时间 :
周一~~周五
9:00 -18:00
在非工作时间,您可以通过邮件订购产品,订购时请写明详细联系方式,谢谢支持!
销售:18321282235
技术:021-60514606
传真:021-37680378
顾经理微信 扫一扫,关注我们
ARHGDIA Polyclonal Antibody
ARHGDIA; GDIA1; MGC117248; RHOGDI; RHOGDI-1
货号:YBAP11919 |
|
![]() |
|
规格: 50ul/100ul/200ul |
|
价格: 980/1280/1890 |
Immunogen: | Recombinant protein of human ARHGDIA | ||
Synonym: |
ARHGDIA; GDIA1; MGC117248; RHOGDI; RHOGDI-1 | ||
Calculated MW: | 23kDa | ||
Observed MW: | Refer to figures | ||
Source: |
Rabbit |
Isotype: |
IgG | ||
Application: |
WB | ||
Purify: |
Affinity purification | ||
Concentration: |
3.29mg/ml | ||
Storage Buffer: |
PBS with 0.05% sodium azide, 50% glycerol, pH7.3 | ||
Storage: |
Store at -20℃. Avoid freeze / thaw cycles. |
Western blot analysis of Jurkat, 293, A431, Hela and HL60 cell, mouse pancreas tissue, using ARHGDIA Polyclonal Antibody at dilution of 1:500 |
Protocols: |
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide |
||
Background: |
Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI). RhoGDI affects Rho activity by inhibiting nucleotide exchange and membrane association, regulating activity and localization. The inhibitory and shuttling functions of RhoGDI have been uncoupled using mutant forms of RhoGDI. Phosphorylation of GDIs and/or GTPases can modulate their affinity for each other and, therefore, GTPase mediated signaling. PAK1 phosphorylation of RhoGDI at serines 101 and 174 causes release and activation of Rac1, but not RhoA.
|
部门 |
姓名 | 手机 | |||
销售部 | 顾先生 | 1916510334@qq.com | 18321282235 | 1916510334 | |
技术部 | 技术支持 | 1781364813@qq.com | 13816899465 | 1781364813 |
全国免费电话:18321282235
销售: 18321282235
86-21-60514606
技术: 13816899465
传真: 021-37680378
The latest products