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RUNX1 Polyclonal Antibody
AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2Ab
货号:YBAP12018
价格: 980/1280/1890
Immunogen: Synthetic peptide of human RUNX1
Synonym:
AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2Ab
Calculated MW: 51kDa
Observed MW: Refer to figures
Source:
Rabbit
Isotype:
IgG
Reactivity: H,M,R;

Clonality: Polyclonal


Application:
WB
Purify:
Affinity purification
Concentration:
5.09mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
RUNX1 Polyclonal Antibody


Western blot analysis of SH-SY5Y cell, mouse liver and spleen tissue, using RUNX1 Polyclonal Antibody at dilution of 1:500

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1-ETO, t(12;21) TEL-AML, and t(8;21) AML-M2. Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner.

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